EPINEPHRINE AND URINE FORMATION IN THE FROG

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Abstract
In intact frogs with cloacas ligated, no significant changes in rate of urine formation could be found in 2-hr. periods, either by injection of epinephrine or by immersion in solutions of it. In pithed frogs kept in an atmosphere of oxygen, one kidney was exposed for microscopic examination and the ureter leading from it was cannulated. Epinephrine, injected either subcutan. or intraven., produced extreme oliguria of a few minutes'' duration. This oliguria coincided with sudden diminution of blood flow in the glomeruli of the kidney. Poly-uria of longer duration followed, together with increase of heart rate. The renal effects of epinephrine represent its actions upon distinct portions of the circulatory system; local effects in renal arterioles led to oliguria, systemic effects in the blood vessels led to polyuria.

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