THE LIPID SOLUBILITY OF PORPHYRINS MODULATES THEIR PHOTOTOXICITY IN MEMBRANE MODELS
- 1 May 1983
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 37 (5) , 487-490
- https://doi.org/10.1111/j.1751-1097.1983.tb04505.x
Abstract
The photosensitizing activities of hematoporphyrin, Cu‐hematoporphyrin, protoporphyrin. Zn‐protoporphyrin, deuteroporphyrin and uroporphyrin are studied. The relative yields of1O2are measured in buffer (pH 8.0) and compared to the yields of Type II photodamages induced on cholesterol embedded in egg lecithin liposomes. Results show that the solubilization of the sensitizer in the lipid bilayer is a prerequisite for its photosensitizing activity at the membrane level. In this context, the partition coefficient represents an important parameter.This publication has 23 references indexed in Scilit:
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