Beziehungen Zwischen Biochemischen Veränderungen und Mortalität Nach Ganzkörperbestrahlung von Mäusen

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Abstract
The enzymatic activities of kynureninase and 5-hydroxy-tryptophan decarboxylase were investigated in the liver tissue of whole-body irradiated mice. Some days after irradiation a decrease of activity was observed with radiation doses higher than 500 R. This effect increased with doses up to 700 R. There was a pronounced correlation between the observed biochemical changes and the survival rate of animals with respect to radiation dose and time. Both reactions after irradiation were influenced in the same way by the prophylactic application of 5-hydroxytryptamine. The relation between the biochemical systems and radiation sickness and the possibility of using these biochemical changes for the diagnosis of radiation damage are discussed.