Life and Death Decisions
- 10 January 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 299 (5604) , 214-215
- https://doi.org/10.1126/science.1081274
Abstract
Screening small molecules for their ability to perturb a cellular pathway, a strategy called forward chemical genetics, can yield unexpected information about other pathway components. This is well illustrated by new work ([Jiang][1] et al .), as [Nicholson and Thornberry][2] discuss in their Perspective. Discovery of a small-molecule activator of apoptosis implicated a tumor suppressor protein and an oncoprotein in the regulation of the mitochondrial cell death pathway. [1]: http://www.sciencemag.org/cgi/content/short/299/5604/223 [2]: http://www.sciencemag.org/cgi/content/full/299/5604/214Keywords
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