THE SYNTHESIS OF DI- AND TRITHIOLS

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Abstract
In the course of a study of antidotes to lewisite the following thiols have been prepared from the corresponding di- and trihalides by the action of sodium hydrosulphide or ammonium hydrosulphide in ethanol under pressure: 1,2-dimercaptoethane, 1,2-dimercaptopropane, 1,3-dimercaptopropane, 1,2,3-trimercaptopropane, 1,2-dimercapto-n-butane, 2,2′-dimercaptoethyl ether, 3,3′-dimercaptopropyl ether, 2,2′-dimercaptoisopropyl ether, and 1,3-dimercapto-2-propanol.1,2-Dimercaptopropane has been prepared by a new method, namely, by the interaction of ammonium hydrosulphide and allyl bromide. This method involves the addition of hydrogen sulphide to an unsaturated compound by the action of ammonium hydrosulphide in ethanol under pressure.The toxicity of the above thiols and their antidotal activity to lewisite have been compared with those of 2,3-dimercaptopropanol (BAL, British anti-lewisite) and the results of these studies will be published later.

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