Metronidazole, its Bioactive Metabolites and Acne
- 1 January 1999
- journal article
- Published by Taylor & Francis in Current Medical Research and Opinion
- Vol. 15 (4) , 298-299
- https://doi.org/10.1185/03007999909116500
Abstract
SummaryMetronidazole's activity has been established in both acneform rosacea and acne vulgaris. Recent research indicating that the breakdown products of several antibiotics, including metronidazole, may have considerably greater activity than the parent compound, prompted a re-examination of the susceptibility of Propionibacterium acnes, the organism involved in the fundamental pathogenesis of acne vulgaris. Although the organism was marginally more sensitive to the hydroxy derivative, MIC levels were still outside the readily attainable therapeutic range. The beneficial effects of metronidazole in acne vulgaris are attributable to its anti-inflammatory activities rather than its antibacterial ones.Keywords
This publication has 10 references indexed in Scilit:
- Therapy for Acne VulgarisNew England Journal of Medicine, 1997
- Clinical Pharmacokinetics of Metronidazole and Other Nitroimidazole Anti-InfectivesClinical Pharmacokinetics, 1992
- Activity of clarithromycin and its principal human metabolite against Haemophilus influenzaeAntimicrobial Agents and Chemotherapy, 1991
- IntroductionDiagnostic Microbiology and Infectious Disease, 1989
- Susceptibility of campylobacter species to metronidazole, its bioactive metabolites and tinidazoleInfection, 1987
- Treatment of rosacea with 1% metronidazole cream. A double-blind studyBritish Journal of Dermatology, 1983
- SENSITIVITY OF GARDNERELLA VAGINALIS TO METABOLITES OF METRONIDAZOLE AND TINIDAZOLEThe Lancet, 1982
- Metronidazole and acneActa Dermato-Venereologica, 1975
- Susceptibility of Anaerobic Bacteria to Metronidazole: Relative Resistance of Non-Spore-Forming Gram-Positive BaccilliThe Journal of Infectious Diseases, 1975