Pineal Serotonin N -Acetyltransferase: Expression Cloning and Molecular Analysis
- 8 December 1995
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 270 (5242) , 1681-1683
- https://doi.org/10.1126/science.270.5242.1681
Abstract
Pineal serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that coordinates daily and seasonal physiology in some mammals. Complementary DNA encoding ovine AA-NAT was cloned. The abundance of AA-NAT messenger RNA (mRNA) during the day was high in the ovine pineal gland and somewhat lower in retina. AA-NAT mRNA was found unexpectedly in the pituitary gland and in some brain regions. The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases.Keywords
This publication has 28 references indexed in Scilit:
- Calcium Potentiates Cyclic AMP Stimulation of Pineal Arylalkylamine N‐AcetyltransferaseJournal of Neurochemistry, 1993
- Binding of nucleotides by proteinsCurrent Opinion in Structural Biology, 1992
- Melatonin synthesis in chicken retina: Effect of kainic acid-induced lesions on the diurnal rhythm and D2-dopamine receptor-mediated regulation of serotonin N-acetyltransferase activityNeuroscience Letters, 1992
- Basic local alignment search toolJournal of Molecular Biology, 1990
- Involvement of Calcium in the Regulation of Serotonin N‐Acetyltransferase in RetinaJournal of Neurochemistry, 1986
- Rapid Nocturnal Increase in Ovine Pineal N‐Acetyltransferase Activity and Melatonin Synthesis: Effects of CycloheximideJournal of Neurochemistry, 1985
- Pineal N -Acetyltransferase Is Inactivated by Disulfide-Containing Peptides: Insulin Is the Most PotentScience, 1981
- Pineal Serotonin N -Acetyltransferase Activity: Abrupt Decrease in Adenosine 3′,5′-Monophosphate May Be Signal for "Turnoff"Science, 1978
- Characteristics of serotonin‐acetyl coenzyme A N‐acetyltransferase in pineal gland of ratJournal of Neurochemistry, 1975
- Rapid Light-Induced Decrease in Pineal Serotonin N -Acetyltransferase ActivityScience, 1972