Effect of Dibenamine on Renal Blood Flow in Hemorrhagic Shock

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Abstract
19 anesthetized dogs were subjected to a standardized bleeding procedure; 8 served as controls while 11 were given 3 or 6 mg./kg. of Dibenamine at the middle of the 50-mm. Hg hypotensive periods. Renal blood flow (RBF) was measured directly at frequent intervals. The animals receiving Dibenamine showed an increase in RBF during the hypotensive periods and maintained a somewhat better blood flow after reinfusion of blood. The pressure/flow relationship in the kidney revealed a lower vascular resistance in the Dibenamine-treated group during comparable stages following bleeding and development of hemorrhagic shock. The effect of delayed renal failure on the survival of animals could of course not be evaluated in these expts. Dibenamine did not prolong survival and no correlation between RBF and survival rate could be demonstrated in hemorrhagic shock.

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