Most of the avian genome appears available for retroviral DNA integration
- 1 November 1994
- Vol. 16 (11) , 797-799
- https://doi.org/10.1002/bies.950161105
Abstract
Although retroviral integration requires specific viral DNA sequences, factors which govern the choice of a chromosomal target site within an infected celi are less clear. For example, certain chromosomal regions may be inaccessible to the viral integration machinery, while others may favor integration. A recent paper by Withers‐Ward et al.(1) addresses this issue using a polymerase chain reaction‐based assay capable of identifying single integration events within a large population of infected cells. Their results show that integration can occur into many different chromosomal regions, and that local DNA structure can influence the site of integration within a given region.Keywords
This publication has 16 references indexed in Scilit:
- Distribution of targets for avian retrovirus DNA integration in vivo.Genes & Development, 1994
- Nonrandom integration of retroviral DNA in vitro: effect of CpG methylation.Proceedings of the National Academy of Sciences, 1992
- Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selectionCell, 1992
- Chromatin as an essential part of the transcriptional mechanimNature, 1992
- Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA.Proceedings of the National Academy of Sciences, 1991
- The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitroCell, 1990
- The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitroCell, 1990
- Integration of human immunodeficiency virus type 1 DNA in vitro.Proceedings of the National Academy of Sciences, 1990
- Correct integration of retroviral DNA in vitroCell, 1987
- CpG-rich islands and the function of DNA methylationNature, 1986