A hydrophilic plasma polymerized film composite with potential application as an interface for biomaterials

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Abstract
A hydrophilic polymer composite film (approx. 420 nm thick), with potential application as an interface for biomaterials has been prepared on nonorganic substrates, which include glass, silicon, and aluminum foil, using a glow discharge plasma polymerization technique. A thin film (110 nm thick) polymerized from hexane provided an adherent protective coating for the substrate material, and covalent bonding sites for the outer layer polymerized fromN‐vinyl‐2‐pyrrolidone. This outer layer provided the hydrophilic surface or interface. The two layers were copolymerized for a short period during transition between monomers to provide an intimate covalently bonded diffuse interphase. Preliminaryin vitroandin vivobiocompatibility studies indicate that the hydrophilic film is non‐cytotoxic, and does not increase the inflammatory response when compared with negative controls.