INHIBITION OF CYCLIC AMP-MEDIATED INTESTINAL HYPERSECRETION BY PITUITARY EXTRACTS FROM RATS PRETREATED WITH CHOLERA-TOXIN
- 1 January 1984
- journal article
- research article
- Vol. 62 (5) , 290-294
Abstract
Peroral pretreatment with cholera toxin (CT) in rats induced protection against intestinal hypersecretion by CT or prostaglandin E1 (PGE1). Pituitary glands from these CT-pretreated rats were homogenized and injected i.v. or intraluminally into untreated rats. These recipients became resistant to CT. as well as to PGE1-induced hypersecretion; recipients given pituitary extracts from control animals responded normally. Extracts of intestinal mucosa from CT-pretreated, but not from control rats, also inhibited secretion by CT. Ultrafiltration experiments with the pituitary or intestinal extracts indicated that the antisecretory factors had a MW between 10,000 and 50,000.This publication has 3 references indexed in Scilit:
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