STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
Open Access
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 11 (1) , 568-572
- https://doi.org/10.1128/mcb.11.1.568
Abstract
We have cloned a novel kinase (STY) from an embryonal carcinoma cell line. Sequence analysis of the STY cDNA reveals that it shares sequence homology with serine/threonine-type kinases and yet the bacterial expression product of the STY cDNA appears to have serine-, threonine-, and tyrosine-phosphorylating activities. The predicted STY protein is highly basic and contains a putative nuclear localization signal. During differentiation, two new mRNAs were detected in addition to the embryonic transcript.Keywords
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