Antidiuretic effects of oxytocin in the Brattleboro rat

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Abstract
The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 μg/h, 1.0 μg/h, and 5 μg/h of OT. OT infused at the rate of 5 μg/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity.