Antidiuretic Responses of Rats with Hereditary Hypothalamic Diabetes Insipidus to Vasopressin, Oxytocin and Nicotine

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Abstract
Rats with hereditary hypothalamic diabetes insipidus (DI) of the Brattleboro strain almost certainly do not secrete vasopressin although they do possess oxytocin. DI rats under ethanol anesthesia were tested for their sensitivity to the antidiuretic effects of iv arginine vasopressin, oxytocin and nicotine. They were about twice as sensitive to vasopressin, oxytocin as were normals. DI rats did not show typical prolonged oliguric responses to iv doses of nicotine that were effective in normal rats. DI rats may thus prove useful as experimental animals when it is particularly important to avoid interference from endogenous vasopressin release.