Effect of X-Irradiation and Hypophysectomy on Globule Leucocytes In Rat Intestine.

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Abstract
Within 4 days after whole body X-irradiation (650 r), globule leukocytes were reduced to 1-2% of their normal number in the intestine of the rat. Re-establishment of normal numbers of cells began toward end of the 1st week after irradiation and was completed by the 5th week. The effect of irradiation on globule leukocytes was chiefly a local one, being prevented by shielding the intestine with lead during irradiation. Only with the LD100 30 days dosage (800 r) was there a significant reduction in number of globule leukocytes in lead-shielded intestinal segments. This appeared to be the indirect result of stress induced by irradiation, since the effect was prevented by hypophysectomy. Hypophysectomy alone reduced markedly the number of intestinal globule leukocytes.