Fine Specificity and Cytolytic Activity of Continuously Growing Alloreactive Cytotoxic T Lymphocyte Clones
- 1 April 1980
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 11 (4) , 449-453
- https://doi.org/10.1111/j.1365-3083.1980.tb00012.x
Abstract
The role of Lyt I+ T[thymus-derived]-cell-derived secondary CTL [cytotoxic T lymphocyte]-inducing factor allowed the cloning of alloreactive [mouse CTL] by the limiting dilution approach. Several monoclonal cell lines were established in vitro. The lytic activity of some of the cell lines exceeded that of CTL from bulk cultures; 50% of the target cells were lysed at an effector to target cell ratio of 0.04:1. The fine specificity of individual CTL clones is discussed.This publication has 16 references indexed in Scilit:
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