Relative affinities of estramustine phosphate metabolites to the cytosol oestrogen receptor of rat testis
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 46 (2) , 159-162
- https://doi.org/10.3109/00365518609083652
Abstract
A competitive binding assay was used for analysis of the affinities of ethinyl oestradiol, diethylstilboestrol and metabolites of estramustine phosphate to the oestrogen receptor of rat testis. The affinities were ranked as follows: ethinyl oestradiol > oestradiol-17β > diethylstilboestrol » estramustine. Estramustine did not reveal any oestrogen receptor affinity. The results support the concept that estramustine and estromustine do not mediate the oestrogenic effects of estramustine phosphate. The oestrogenicity of estramustine phosphate is suggested to be mainly due to the metabolite oestradiol-17βKeywords
This publication has 11 references indexed in Scilit:
- The acute effect of oestrogens on testosterone production appears not to be mediated by testicular oestrogen receptorsMolecular and Cellular Endocrinology, 1983
- Estramustine binding in rat, baboon and human prostate measured by high pressure liquid chromatographySteroids, 1981
- Plasma Concentrations of Estramustine Phosphate and Its Major Metabolites in Patients with Prostatic Carcinoma Treated with Different Doses of Estramustine Phosphate (Estracyt®).Scandinavian Journal of Urology and Nephrology, 1981
- Estrogen Receptors in the MaleArchives of Andrology, 1981
- High dose estrogen response of the hormone independent R3327-At Copenhagen rat prostatic tumorCancer Letters, 1980
- A Comparison of Plasma Protein Changes Induced by Danazol, Pregnancy, and Estrogens*Journal of Clinical Endocrinology & Metabolism, 1979
- Inhibitory effects of estracyt on R-3327 rat prostatic carcinomaUrology, 1977
- Regression of prostatic cancer metastasis by high doses of diethylstilbestrol diphosphateUrology, 1976
- High-affinity binding of oestradiol-17β by cytosols from testis interstitial tissue, pituitary, adrenal, liver and accessory sex glands of the male ratBiochemical Journal, 1974
- Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissuesBiochemical Journal, 1952