Collagen Films: Effect of Cross-Linking on Physical and Biological Properties
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 1 (4) , 703-715
- https://doi.org/10.3109/10731197309118571
Abstract
Enzyme-solubilized collagen was cast into films with different fibrillar structures and cross-linked with glutaraldehyde. Cross-linked films had decreased swelling ratios, decreased degree of hydrolysis, increased resistance to bacterial collagenase, and increased shrinkage temperatures. Subcutaneous implantation in rabbits indicated that cross-linked films could survive for at least 90 days virtually unchanged and surrounded by a fibrous cuff. Cells were able to grow on the collagen surfaces. These studies indicate that collagen, a natural polymer, can be used where long-lasting biomaterials are required.Keywords
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