Nitric oxide: NO apoptosis or turning it ON?
Top Cited Papers
- 17 July 2003
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 10 (8) , 864-869
- https://doi.org/10.1038/sj.cdd.4401261
Abstract
Nitric oxide (NO) is known for its diverse activities throughout biology. Among signaling qualities, NO affects cellular decisions of life and death either by turning on apoptotic pathways or by shutting them off. Although copious reports support both notions, the dichotomy of NO actions remains unsolved. Proapoptotic pathways of NO are compatible with established signaling circuits appreciated for mitochondria-dependent roads of death, with some emphasis on the involvement of the tumor suppressor p53 as a target during cell death execution. Antiapoptotic actions of NO are numerous, ranging from an immediate interference with proapoptotic signaling cascades to long-lasting effects based on expression of cell protective proteins with some interest on the ability of NO-redox species to block caspases by S-nitrosylation/S-nitrosation. Summarizing emerging concepts to understand p53 accumulation on the one hand while proposing inhibition of procaspase processing on the other may help to define the pro- versus antiapoptotic roles of NO.Keywords
This publication has 78 references indexed in Scilit:
- Nitric oxide induces phosphorylation of p53 and impairs nuclear exportOncogene, 2003
- p53 Activation by Nitric Oxide Involves Down-regulation of Mdm2Published by Elsevier ,2002
- A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced PhosphorylationScience, 2001
- Nitric Oxide as a Bioregulator of ApoptosisBiochemical and Biophysical Research Communications, 2001
- Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrestOncogene, 2000
- A Comparative Study of Apoptosis and Necrosis in HepG2 Cells: Oxidant-Induced Caspase Inactivation Leads to NecrosisBiochemical and Biophysical Research Communications, 1999
- Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-NitrosylationBiochemical and Biophysical Research Communications, 1997
- Inhibition of Caspase-3 by S-Nitrosation and Oxidation Caused by Nitric OxideBiochemical and Biophysical Research Communications, 1997
- Nitric Oxide Inhibits CPP32-like Activity under Redox RegulationBiochemical and Biophysical Research Communications, 1997
- p53 expression in nitric oxide‐induced apoptosisFEBS Letters, 1994