Synthesis, DNA-binding, and Antiviral Activity of Certain Pyrazolo[3,4-d]pyrimidine Derivatives
- 1 April 2000
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 333 (4) , 99-103
- https://doi.org/10.1002/(sici)1521-4184(20004)333:4<99::aid-ardp99>3.0.co;2-o
Abstract
Some new pyrazolo[3,4-d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA-binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 μg/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of viral plaques of Herpes simplex type-1 (HSV-1) by 66 and 41%, respectively. The detailed synthesis and spectroscopic and biological data are reported.Keywords
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