CHRONIC INFLAMMATORY BOWEL-DISEASE - INCREASED PLASMINOGEN-ACTIVATOR SECRETION BY MONONUCLEAR PHAGOCYTES

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 48  (1) , 256-260
Abstract
The secretion of the neutral protease plasminogen activator (PA) by cultured macrophages (M.PHI.) was studied in hospitalized patients with chronic inflammatory bowel disease (IBD). There was markedly enhanced secretion of PA by M.PHI. derived from circulating monocytes of the IBD population (18) compared to an age-matched population (16) which was not afflicted by intestinal disease (P < 0.001). Mean M.PHI. PA activity was greater in the population of 11 Crohn''s disease patients (P < 0.01) than in a group of 7 ulcerative colitis sufferers (P < 0.05) when compared to the control population. While both the treated and untreated hospitalized IBD populations showed increased M.PHI. PA specific activity, results for the 9 untreated patients (5.56 .+-. 1.14 U/.mu.g M.PHI. DNA were substantially higher than those found in the IBD population (2.91 .+-. 0.62 U/.mu.g M.PHI. DNA) (P < 0.01). These findings reflect the activity of M.PHI. in IBD and suggest a means by which tissue injury is mediated in these conditions.