CLEARANCE OF ALLANTOIN IN THE RAT AND DOG AS A MEASURE OF GLOMERULAR FILTRATION RATES

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Abstract
The renal clearance of endogenous allantoin was measured in 20 rats and that of creatinine in an additional 17 rats. The mean values were respectively 33.7 and 34.6 ml./hr./100 g. of rat. The renal clearances of endogenous allantoin and of creatinine were measured concomitantly 9 times in 4 dogs, respective mean values found being 85.5 and 90.0 ml./min./meter2 surface area. The renal clearance of allantoin, after plasma concn. was increased up to 45 times the avg. endogenous level, was measured 11 times on 5 dogs concomitantly with the creatinine clearance. The respective mean values were 89.9 and 89.3 ml./min./meter2 surface area. These observations indicated that the clearance of allantoin is at the level of glomerular filtration in the rat and dog.

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