Metastasizing Carcinoma of the Stomach in Peutz-Jeghers Syndrome

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Abstract
There have been conflicting views as to the frequency with which malignant change occurs in the polyps associated with the Peutz-Jeghers syndrome. This has been due to the difficulty in interpreting the histologic structure of the polyp. There has been agreement that the lesions are hamartomas and benign. There has been no case reported of unequivocal metastases from a carcinoma of the small or large intestine associated with the syndrome. The case described and recent reports of metastasizing carcinoma in the stomach and duodenum associated with the Peutz-Jeghers syndrome lead to the conclusion that at least in these areas the syndrome cannot be dismissed as completely benign.