A novel approach towards the synthesis of pyrophosphate analogues of farnesyl pyrophosphate
- 1 January 1994
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 113 (12) , 563-566
- https://doi.org/10.1002/recl.19941131206
Abstract
The synthesis of two new analogues (i.e. 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.Keywords
This publication has 13 references indexed in Scilit:
- PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUESAnnual Review of Biochemistry, 1992
- The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interactionJournal of the American Chemical Society, 1991
- Isoprenyl phosphinylformates: new inhibitors of squalene synthetaseJournal of Medicinal Chemistry, 1991
- An Expeditious Synthesis of Pyrophosphate Analogues of Farnesyl Pyrophosphate Using the Phosphonylating Agent Methyl MethylphosphonomorpholidateSynlett, 1991
- The synthesis of isoprenoid (phosphinylmethyl)phosphonatesTetrahedron, 1990
- Synthesis and reactivity of diethyl phosphonomethyltriflateTetrahedron Letters, 1986
- Inhibition of squalene synthetase by farnesyl pyrophosphate analogsJournal of Medicinal Chemistry, 1977
- Application of unreactive analogs of terpenoid pyrophosphates to studies of multistep biosynthesis. Demonstration that "presqualene pyrophosphate" is an essential intermediate on the path to squaleneJournal of the American Chemical Society, 1976
- A method for selective conversion of allylic and benzylic alcohols to halides under neutral conditionsTetrahedron Letters, 1972
- Nucleoside Polyphosphates. X.1 The Synthesis and Some Reactions of Nucleoside-5' Phosphoromorpholidates and Related Compounds. Improved Methods for the Preparation of Nucleoside-5' Polyphosphates1Journal of the American Chemical Society, 1961