Nasal potential difference: a clinical diagnostic test for cystic fibrosis
- 1 September 1990
- journal article
- research article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 3 (8) , 922-926
- https://doi.org/10.1183/09031936.93.03080922
Abstract
Patients with cystic fibrosis (CF) demonstrate a markedly more negative potential difference (PD) across respiratory epithelia than normal or "diseased" controls. A technique is described for the measurement of nasal PD in both children and adults. 145 non-CF subjects showed a mean PD of -19.0 mV (range -2 to -36) in comparison to 60 patients with cystic fibrosis with mean of -46.0 mV (range -32 to -77). Amongst the latter group those with more severe disease had a more negative PD. Measurement of nasal PD is easily learnt and rapidly performed and may provide an additional means of diagnosis for CF.This publication has 9 references indexed in Scilit:
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