Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase
- 15 October 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (20) , 10530-10532
- https://doi.org/10.1128/jvi.76.20.10530-10532.2002
Abstract
We demonstrate that human herpesvirus 8, obtained from the lymphoma cell line BC-3 as well as from Kaposi's sarcoma lesions, carries a gene that encodes a functional thymidylate synthase (TS). The particular characteristics of this enzyme are studied and compared to the characteristics of TSs encoded by other organisms.Keywords
This publication has 22 references indexed in Scilit:
- The molecular pathology of Kaposi’s sarcoma-associated herpesvirusBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002
- Molecular virology of Kaposi's sarcoma–associated herpesvirusPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2001
- Dihydrofolate Reductase from Kaposi's Sarcoma-Associated HerpesvirusVirology, 2000
- Human Cytomegalovirus Stimulates Thymidylate Synthase in Human Embryonic Lung Cells: A Possible Target for Anti-HCMV Therapy?Nucleosides, Nucleotides and Nucleic Acids, 1995
- Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formationBiochemistry, 1992
- Varicella-Zoster Virus Specifies a Thymidylate SynthetaseJournal of General Virology, 1987
- The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase.Proceedings of the National Academy of Sciences, 1986
- Inhibition of mammalian tumour thymidylate synthetase by 5-alkylated 2′-deoxyuridine 5′-phosphatesBiochemical Pharmacology, 1984
- 5-substituted 2′-deoxyuridines: Correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetaseBiochemical Pharmacology, 1982
- Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationshipJournal of Medicinal Chemistry, 1977