Plasminogen Phenotypes in a Japanese Population
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 39 (6) , 356-360
- https://doi.org/10.1159/000153888
Abstract
Human plasminogen (PLG) phenotypes were investigated by polyacrylamide gel isoelectric focusing followed by immunoblotting. In 5,735 plasma samples from unrelated, healthy Japanese individuals, four new variants were detected and tentatively designated PLG AOsaka, PLG BOsaka, PLG M°saka and PLG ANara. The plasminogen concentrations and activities of the PLG phenotypes were studied. In agreement with previous studies PLG M5 was found to have a decreased activity. The new variant PLG MOsaka had a very low activity and appears to be an abnormal plasminogen with a functional defect similar to that of PLG M5.Keywords
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