GENETIC-POLYMORPHISM OF HUMAN-PLASMINOGEN
- 1 January 1980
- journal article
- research article
- Vol. 32 (5) , 681-689
Abstract
Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation or caseinolytic overlay after urokinase activation of gels, a common genetic polymorphism in human plasminogen was delineated. Two alleles (PLGN*A and PLGN*B) were observed with gene frequencies in whites of 0.69 and 0.30; in Orientals of 0.96 and 0.03; and in blocks of 0.80 and 0.18. Several rare alleles were also found. The distribution of phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant and fits the expectations of Mendelian inheritance. There is fetal synthesis, but no transplacental passage of plasminogen in either direction.This publication has 17 references indexed in Scilit:
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