Antihypertensive Effect of Trichlormethiazide in Spontaneously Hypertensive Rats

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Abstract
Antihypertensive and diuretic effects of trichlormethiazide (TCM) were investigated in the spontaneously hypertensive rats (SHR). The antihypertensive effect of TCM in an acute experiment was observed in male SHR only at a dose over 10 mg/kg given i.p. and not in female SHR and normotensive Kyoto Wistar rats. In a subacute experiment (6 wk), TCM retarded the development of hypertension in the male SHR loaded with 1% saline solution at an oral dose over 1 mg/kg per day and such had a diuretic effect. Oral administration of TCM and hydrochlorothiazide (HCT) at 10 mg/kg per day retarded the development of hypertension in the saline loaded female SHR to the same degree, but the relationship between antihypertensive and diuretic effects of both compounds was obscure. Except for decreases of water content in the thoracic artery and wet weight of hearts, the electrolyte, uric acid, catecholamine and 5-hydroxytryptamine contents in the serum and/or organs were not affected by either TCM or HCT. The antihypertensive effect of TCM and HCT was observed in SHR with a saline-load and the effect may be due to diuretic actions in the male. The relationship was not apparent in female SHR.