Effects of changes of blood pressure, respiratory acidosis and hypoxia on blood flow in the sciatic nerve of the rat.

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Abstract
Using the H-clearance technique, blood flow was measured in the sciatic nerves of healthy, anesthetized rats at rest, at various arterial blood pressures, and during respiratory acidosis and hypoxia. The majority of H-clearance curves were bi-exponential. The slower component appears to reflect nerve blood flow more accurately than either the fast component or the composite value obtained from both components. Mean nerve blood flow estimated from the slow component of the 17 bi-exponential H-clearance curves and from the 7 mono-exponential curves was 15.8 .+-. 1.1 ml min-1 100 g-1 (.+-. SE of the mean). The mean value of the fast component of the bi-exponential curves was 118 .+-. 6 ml min-1 100 g-1 and that obtained from both components was 25.9 .+-. 2.6 ml min-1 100 g-1. Sciatic nerve blood flow was measured over a range of arterial blood pressures of 60-160 mm Hg. There is a curvilinear relationship between pressure and flow suggesting that the nerve vascular bed responds passively to changes in perfusion pressure. Respiratory acidosis resulted in no significant change in nerve blood flow. The mean flow was 15.5 .+-. 1.9 ml min-1 100 g-1. During hypoxia, nerve blood flow decreased to 7.5 .+-. 1.4 ml min-1 100 g-1 as a result of a reduction in arterial blood pressure and an increase in vascular resistance. Normal nerve blood flow apparently high in relation to metabolic activity, especially when compared with the brain.

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