Renin-sodium profile in experimental nephrosis induced by puromycin aminonucleoside.

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Abstract
The roles of the renin-angiotensin system (RAS) and aldosterone in the pathogenesis of nephrotic syndrome were investigated with rats following s.c. injections of puromycin aminonucleoside (PAN) for 7 d [day]. Prominent reduction in plasma renin activity (PRA) was observed at day 15 after the initial treatment with PAN preceded by the onset of the nephrosis and there was no significant difference in plasma aldosterone concentration (PAC) between the nephrosis and normal control groups despite the higher levels obtained in the nephrosis animals. Although the precise mechanism of reduction in PRA was not elucidated, neither the RAS nor aldosterone secretion apparently played a primary role in the pathogenesis of the nephrosis. PAN induced nephrosis is interesting in studying the pathophysiological mechanism of the lowered activity of plasma renin in some patients with nephrotic syndrome.