PRENEOPLASTIC STAGE IN THE SPONTANEOUS NEOPLASTIC TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS IN CULTURE
- 1 January 1980
- journal article
- research article
- Vol. 40 (1) , 91-94
Abstract
Spontaneous neoplastic transformation of Syrian hamster embryo cells in culture occurs in at least 2 steps. An intermediate stage is represented by an aneuploid cell line [GSHE] which is preneoplastic. These cells differ from the diploid cells by a number of properties, including their ability to become neoplastic in vivo when injected while attached to a substrate. A multistep process for neoplastic transformation of cells in vitro was suggested and caution against considering aneuploid cell lines as normal cells should be taken.This publication has 12 references indexed in Scilit:
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