Microassay for Studying Anticellular Effects of Human Interferons

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Abstract
A microassay has been developed to quantitate anticellular effects of beta and gamma IFNs. This assay is simple and capable of titrating a large number of IFN samples and doses with multiple sets of target tumor cells. The ranking of results from the microassay was comparable to that obtained using a more complex procedure. The microassay required 5-10 times smaller amounts of reagents than other procedures, and is capable of being applied to other chemotherapeutic agents as well. The susceptibility of human tumor cell lines to anticellular effects of IFN-gamma was clearly distinct from susceptibility to IFN-beta.

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