The effect of ambient temperature on experimental histoplasmosis of the mouse

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Abstract
Histoplasma capsulatum was cultured from the liver of 55.1% of mice 3 months after peritoneal inoculation and kept at an amibient temperature of 10° C., and from 14.8% of mice kept at 35–37° C. Since the H. capsulatum strain used does not grow at 40° C. and since the inner temperature of the mouse rises close to this value when placed at 35–35° C., a direct unfavourable effect of the body temperature on the fungus should be considered. It is suspected that the climate may have an influence on the frequency and severity of the clinical manifestations of histoplasmosis in the man. Histoplasma capsulatum fue receuperado en cultivo del hígado del 55, 1 por ciento de los ratones inoculados intrapertionealmente tres meses antes y mantenidos a una temperatura ambiente de 10° C, y del 14,8 por ciento de los ratones mantenidos a 35–37° C. Dado que la cepa inoculada no crece a 40° C y dado que la temperatura interna del ratón se eleva a valores similares cuando es colocado a 35–37° C, deberá ser considerado un efecto directo de la temperatura corporal desfavorable para el hongo. Se sospecha que el clima puede tener inflencia sobre la frecuencia y la gravedad de la histoplasmosis del hombre.

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