Calcium-antagonists and islet function. IV. effect of D600
Open Access
- 1 March 1976
- journal article
- conference paper
- Published by Springer Nature in Diabetologia
- Vol. 12 (1) , 77-81
- https://doi.org/10.1007/bf01221969
Abstract
D600 (2 to 20 μM;α-isopropyl-α [(N-methyl-N-homoveratril)-γ-aminopropyl]-3,4,5 -trimethoxyphenyl-acetonitril) caused a dose-related, rapid and reversible inhibition of glucose-induced insulin release. It also suppressed the insulinotropic action of a sulphonylurea but failed to affect the enhancing action of theophylline upon glucose-induced release. The inhibitory effect of D600 was enhanced at low extracellular Ca2+ concentration. D600 reduced both basal and glucose-stimulated45calcium net uptake, whilst failing to affect the efflux of45calcium from perifused islets. The recognition of glucose by the B-cell was also unaffected by D600 as judged by the effect of the sugar upon both 45 calcium efflux and net uptake in the isolated islets. These findings are compatible with the hypothesis that the primary mode of action of D600 is to inhibit Ca2+entry in the B-cell.Keywords
This publication has 13 references indexed in Scilit:
- Calcium antagonists and islet function. I. Inhibition of insulin release by verapamilDiabetes, 1975
- Calcium Antagonists and Islet Function: I. Inhibition of Insulin Release by VerapamilDiabetes, 1975
- Dynamics of Insulin Release and Microtubular-Microfilamentous System. I. EFFECT OF CYTOCHALASIN BJournal of Clinical Investigation, 1973
- The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of Theophylline and epinephrine on 45Ca efflux from perifused isletsMetabolism, 1973
- Role of calcium in insulin secretion.1972
- The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. VII. A PROPOSED SITE OF ACTION FOR ADENOSINE-3′,5′-CYCLIC MONOPHOSPHATEJournal of Clinical Investigation, 1972
- [Uterus relaxation by highly potent Ca plus,plus-antagonistic inhibitors of electro-mechanical coupling such as Isoptin (verapamil, iproveratril), compound D 600 and Segontin (prenylamine). Experiments on the isolated virgin rat uterus].1971
- Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. III. Uptake of45Calcium by Isolated Islets of Langerhans1Endocrinology, 1971
- Uterus-Relaxation durch hochaktive Ca++-antagonistische Hemmstoffe der elektro-mechanischen Koppelung wie Isoptin (Verapamil, Iproveratril), Substanz D 600 und Segontin (Prenylamin)Klinische Wochenschrift, 1971
- The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.1970