Synthesis, Physico-Chemical Properties and Immunoadjuvant Activity of Water-Soluble Phosphazene Polyacids
- 1 October 1998
- journal article
- research article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 13 (4) , 243-256
- https://doi.org/10.1177/088391159801300401
Abstract
Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity of polyphosphazenes was evaluated by studying the effect of copolymers on the immunogenicity of the influenza virus in mice. Synthesized polyphosphazenes demonstrated the ability to enhance the immune response as compared to the levels elicited by the vaccine alone.Keywords
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