The Sensitivity of Intracorpuscular Haemoglobin to Oxidation by Nitrite Ions (I) The Effect of Growth, Starvation & Diet

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Abstract
Young and pregnant rats show increased sensitivity to oxidation of their hemoglobin justas do children and pregnant women. The change in sensitivity does not appear to be correlated with puberty. The effects of starvation for 42 hours seem to be the same as those of pregnancy or extreme youth, and the resistance of the hemoglobin in nitrites can be restored by the administration of riboflavin. Riboflavin given subcutaneously markedly increases the resistance of the hemoglobin of young and pregnant rats to oxidation with nitrites, but never quite to the adult level. The method by which riboflavin protects the hemoglobin from oxidation is discussed.