The effect of reserpine and α-methyldopa on the analgesic action of morphine in the mouse

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Abstract
In the tail clip test, reserpine inhibited the analgesic action of morphine, and this action of reserpine was prevented by pretreatment with α-methyldopa. In the hot plate test reserpine potentiated the action of morphine, and α-methyldopa pre- treatment had no inhibitory action on reserpine. α-Methyldopa alone, and in combination with reserpine, showed an analgesic action in the hot plate test.

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