HYPOPHOSPHOREMIC OSTEOMALACIA SECONDARY TO BENIGN CONNECTIVE-TISSUE TUMORS - A REPORT ON 3 UNUSUAL CASES WITH VITAMIN-D METABOLITES MEASUREMENTS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 131  (7) , 422-426
Abstract
Three cases of benign connective tissue tumors (intracranial frontal hemangiopericytoma, rectosigmoid hemangioma, intraspinal neurinoma) associated with hypophosphoremic osteomalacia and reduction in plasma 1-25(OH)2D levels are described. Rapid reversal of biological anomalies and subsequent recovery from clinical manifestations were observed after tumor ablation. Twenty-two identical cases are reported in the literature. The sharp fall in 1-25(OH)2D levels without secondary hypocalcemia or hyperparathyroidism suggests that intestinal absorption of Ca is not entirely dependent on this metabolite. Increased phosphoremia without a parallel rise in 1-25(OH)2D levels was noted in 1 case. The possibility of an existing connective tissue tumor should be explored in all cases of hypophosphoremic osteomalacia.