The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival
- 20 February 2004
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 18 (6) , 627-636
- https://doi.org/10.1096/fj.03-0979rev
Abstract
Protein kinase Cδ (PKCδ) has been implicated both as a tumor suppressor and a positive regulator of cell cycle progression. PKCδ has also been reported to positively and negatively regulate apoptotic programs. This has led to conflicting hypotheses on the role of PKCδ in the control of cell proliferation and survival. Surprisingly, PKCδ mice develop normally and are fertile, indicating that PKCδ is not critical for normal cell proliferation during development. However, PKCδ may play important roles in neoplastic cell proliferation. In this review, we have summarized the apparent multifunctional properties of this enigmatic protein with regard to its role in the regulation of cell cycle progression and cell survival. It is proposed that PKCδ has both tumor suppressor and proliferation capabilities that can be recruited as a backup kinase for both gatekeeper tumor suppression and as an activator of the Ras/Raf/MEK/MAP kinase signaling pathway in cell proliferation.—Jackson, D. N., Foster, D. A. The enigmati...Keywords
Funding Information
- National Cancer Institute
- National Institutes of Health
This publication has 87 references indexed in Scilit:
- Opposing effects of δ- and ζ-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitorsJournal of Molecular and Cellular Cardiology, 2003
- Regulation of cell apoptosis by protein kinase c δApoptosis, 2003
- Increased proliferation of B cells and auto-immunity in mice lacking protein kinase CδNature, 2002
- Exacerbated vein graft arteriosclerosis in protein kinase Cδ–null miceJournal of Clinical Investigation, 2001
- Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts.Carcinogenesis: Integrative Cancer Research, 2000
- Activation of Protein Kinase C Triggers Its Ubiquitination and DegradationMolecular and Cellular Biology, 1998
- Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.Proceedings of the National Academy of Sciences, 1992
- Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursNature, 1992
- THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONSAnnual Review of Biochemistry, 1989
- Chemical Carcinogenesis: From Animal Models To Molecular Models In One DecadePublished by Elsevier ,1988