Immunization of Turkey Breeder Hens against Fowl Cholera by Combined Oral and Wing-Web Administration of Attenuated (CU) Pasteurella multocida

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Abstract
Turkey breeder candidates were exposed to attenuated P. multocida (Clemson University strain) via both mouth (1 or 3 times) and wing-web stick (1 or 2 times). Significant protection lasting to 25-30 wk post-vaccination was conferred under such immunization programs. The best protection with the fewest adverse effects of vaccination was established when orally vaccinated turkeys were subsequently vaccinated via wing-web at 20 and 25 wk of age. High doses of attenuated P. multocida via wing-web produced lameness (synovitis and osteomyelitis) and severe wing lesions in growing turkeys.