HLA-DRW7 AND STEROID-RESPONSIVE NEPHROTIC SYNDROME OF CHILDHOOD

  • 1 January 1980
    • journal article
    • research article
    • Vol. 14  (2) , 71-74
Abstract
Possible immunogenetic markers in steroid-responsive nephrotic syndrome of childhood (SRNS) were studied. The incidence of HLA-DRw7 was significantly greater in SRNS patients than in controls (71% in patients, 29.8% in controls, P < 0.005). The HLA-A and -B locus antigens occurred in normal frequencies. The relative risk factor for HLA-DRw7 in SRNS was 5.9. A relationship between HLA-DRw7 and atopy, use of alkylating agents or occurrence of relapse after remission induced by these agents was not shown. SRNS may be an immunologic disorder whose pathogenesis is related to an MHC[major histocompatibility complex]-linked Ir gene.