Candidiasis of the liver and spleen in childhood.

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Abstract
Four children with acute leukemia and surgically documented candidiasis of the liver and/or spleen were examined with a combination of diagnostic imaging modalities including 99mTc-sulfur colloid and 67Ga- citrate scintigraphy, gray-scale ultrasound and body computed tomography (CT). Abnormalities were detected in every individual examined. 99mTc-sulfur colloid scintigraphy revealed cold areas in the liver or spleen. With 67Ga scintigraphy, these areas were cold in some individuals and hot in others. Gray-scale ultrasound demonstrated hypoechoic lesions with central areas of increased echogenicity in hepatic involvement, and hypoechoic replacement of the spleen in splenic involvement. CT in 1 patient revealed low-density areas without contrast enhancement within the hepatic parenchyma and unsuspected renal involvement.

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