New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct (14;14) and inv(14)
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 72 (1) , 22-24
- https://doi.org/10.1007/bf00278811
Abstract
From a series of 53 patients with ataxia telangiectasia, two large clones with a t tan or tct(14;14) and two with an inv(14) were observed among phytohaemagglutinin (PHA)-stimulated lymphocytes. Smaller clones with the same inv(14) were observed in two other cases. Similar breakpoints may exist, both for t(14;14) and inv(14): q11.1/q11.2 and q32, and it is postulated that the rearrangements are related to a recombination of the α-chain of the T-cell receptor and IgH clusters of genes.This publication has 19 references indexed in Scilit:
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