RECOVERY OF THE HEMOLYSIN RESPONSE IN MOUSE RADIATION CHIMERAS

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Abstract
Recovery of the immune system of mouse radiation chimeras immunized with sheep red blood cells was estimated by enumeration of hemolysin-forming spleen cells and titration of serum hemolytic activity. Both estimates were found to attain normal values in iso-genic chimeras. In allogenic chimeras, the recovery of the hemolysin titer remained subnormal during the 5 mo. of observations; and it was attributed to insufficient number of hemolysin-forming cells in the spleen. The correlation between numbers of hemolysin-formmg spleen cells and hemolysin titer was introduced as a new criterion to evalute the recovery of the immune system of mouse radiation chimeras.