Maternal effect on micronucleus induction in MS/Ae mice

1 January 1990

journal article
research article
Published by Wiley in Environmental and Molecular Mutagenesis

Vol. 15 (3) , 125-130
https://doi.org/10.1002/em.2850150302

Abstract

MS/Ae mice, which are mutagen‐sensitive in both the dominant lethal test and micronucleus test, and CD‐1 mice, which are the parental strain of MS/Ae, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6‐mercaptopurine (6‐MP). Col showed equivocal results. However, MMC and 6‐MP showed differential responses in that both male and female offspring from CD‐1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MS/Ae dams were lower than those from CD‐1 dams regardless of sire strain. Numbers of offspring from MS/Ae dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.

Keywords

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