ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC) AGAINST EPSTEIN-BARR VIRUS-DETERMINED ANTIGENS .2. INDUCTION OF ADCC BY FC-FC RECEPTOR BRIDGING

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (1) , 1-10
Abstract
Four different methods to test ADCC against Epstein-Barr virus (EBV) determined antigens were analyzed. Optimal ADCC was obtained if viral antigens were present during the cytotoxicity reaction. Killing probably was mediated by EBV-related immune-complexes forming Fc-Fc receptor bridges between Fc receptor-bearing effector cells [human lymphocytes] and Fc receptor-bearing target cells [human Burkitt''s lymphoma lymphoblastoid P3HR-1, Daudi and Raji cells]. Only lymphoid target cells with a high expression of Fc receptors were susceptible in this particular system.

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