Viral Lesions Complicating Lymphoma in an Adult: Localized Cytomegalic Inclusion Disease and a Second Viral Infection

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Abstract
Cytomegalic inclusion disease was demonstrated histologically in the adrenal glands of a 65-year-old Negro man with lymphoma of 6 months'' duration. Intranuclear and intracytoplasmic inclusion bodies were present in the giant cells of the lesions in the adrenal glands. Cytomegaly was especially prominent in the peripheral portions of foci of necrosis. There was an esophageal ulcer with intranuclear inclusion bodies in the adjacent cells of the stratified squamous epithelium. Intracytoplasmic inclusion bodies and characteristic cytomegaly were not associated with this lesion. This finding was interpreted as probably a terminal infection by a second virus, possibly herpes simplex. Presumably, the lymphoma predisposed to the infection by a virus, or viruses, in the same manner in which lymphoma seems to predispose to terminal mycotic infections.