LIPOTROPIC ACTION OF LIPOCAIC: A STUDY OF THE EFFECT OF ORAL AND PARENTERAL LIPOCAIC AND ORAL INOSITOL ON THE DIETARY FATTY LIVER OF THE WHITE RAT

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Abstract
The accumulation of fat in the livers of white [male] rats fed a diet of 5% casein, 40% lard, 5% yeast powder, 5% salt mixture, 42% glucose, 2% ruffex and 1% cod liver oil can be prevented by oral or parenteral admn. of defatted acid alcoholic extracts of beef pancreas but not by oral admn. of inositol. Control animals fed the above diet for 20 days averaged 28.76% total liver lipids. Animals fed 1.6% inositol in the diet for 21 days averaged 30.16% liver lipids, while those fed 1.6% pancreas extract for 20 days averaged 5.06% liver lipids. An 8% soln. of the pancreatic extract sterilized by Berkfeld filtration administered daily subcut. in 2.0 ml. amts. to rats fed the basal diet for 20 days reduced liver lipids to 5.08%. This Berkfeld filtered soln. is also incorporated into the basal diet to give a 1.6% concn. of the original extract; liver lipids for animals on such a diet averaged 7.37%.

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