Partial inversion of gene order within a homologous segment on the X Chromosome
- 1 January 1993
- journal article
- Published by Springer Nature in Mammalian Genome
- Vol. 4 (2) , 119-123
- https://doi.org/10.1007/bf00290437
Abstract
The locus for the erthyroid transcription factor, GATA1, has been positioned in the small interval between DXS255 and TIMP on the proximal short arm of the human X Chromosome (Chr) by use of a partial human cDNA clone and a well-characterized somatic cell hybrid panel. Analysis of selected recombinants from 108 Mus musculus x Mus spretus backcross progeny with the same clone confirmed that the homologous murine locus (Gf-1) lies between Otc and the centromere of the mouse X Chr. These data imply that a partial inversion of gene order has occurred within the conserved segment that represents Xp21.1-Xp11.23 in human (CYBB-GATA1) and the proximal 6 cM of the mouse X Chr (Gf-1-Timp). Furthermore, they indicate that the mouse mutant scurfy and the human genetic disorder Wiskott-Aldrich syndrome, which have been mapped to the same regions as GATA1/Gf-1 in both species, may indeed be homologous disorders.Keywords
This publication has 27 references indexed in Scilit:
- Novel Sequences Conserved on the Human and Mouse X ChromosomesGenomics, 1993
- Partial sequence data from three evolutionarily conserved loci from the proximal short arm of the human X chromosome; assignment of DXF34S1 to Xp11.21-cenCytogenetic and Genome Research, 1993
- Mapping of FMR1, the gene implicated in fragile X-linked mental retardation, on the mouse X chromosomeGenomics, 1992
- Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosomeGenomics, 1991
- The properdin structural locus (Pfc) lies close to the locus for tissue inhibitor of metallothionine proteases (Timp) on the mouse X chromosomeGenomics, 1991
- Localization of the gene for the Wiskott-Aldrich syndrome between two flanking markers, TIMP and DXS255, on Xp11.22–Xp11.3Genomics, 1991
- Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of miceGenomics, 1991
- Linkage studies do not confirm the cytogenetic location of incontinentia pigmenti on Xp11Human Genetics, 1988
- Conservation and reorganization of loci on the mammalian X chromosome: A molecular framework for the identification of homologous subchromosomal regions in man and mouseGenomics, 1988
- Mapping of 12 translocation breakpoints in the Xp21 region with respect to the locus for Duchenne muscular dystrophyCytogenetic and Genome Research, 1988